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Beneficial effects have likewise been documented with respect to cardiovascular risk factors, including hypertension (430) and dyslipidemia (431, 432)

Regulatory Status and Legal Considerations Regulatory status varies globally

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Among several NO-releasing prodrugs O 2 -(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) 4 has undergone trials in several animals models and shown promise as a novel prodrug in cancer chemotherapy 5

Oxidase-like activity Oxidase-like activity of pFeSAN was investigated with TMB as substrate in the acetate buffer (pH 4.0, Fig